
Hybridisation Target Enrichment (HTE) is the most commonly used genomic DNA enrichment strategy in NGS studies, but the method has not significantly advanced in recent years. Researchers have now developed products and strategies that significantly improve the performance of HTE.
Whole genome sequencing is not yet cost effective for most applications, so hybridisation targeted enrichment (HTE) remains popular. Existing HTE methods produce: Limited enrichment power, such that they are poorly useful unless targeting >1Mb Uneven recovery, such that many variants are missed or unreliably detected.
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