Screening Method and Reagents for Transfection and Delivery of Biomolecules.

A novel polymeric scaffold to provide flexible and more efficient methods for transfection of cells with active pharmaceutical ingredients.

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Background.

One of the main challenges faced by the pharmaceutical Industry is providing compositions or devices capable of overcoming the cell membrane barrier and deliver active pharmaceutical ingredients to a target cell. This issue is critical in the case of gene therapy, where relatively large lipophobic molecules (e.g. DNA, RNA or siRNA) have to overcome the “hostile” lipophilic cell membrane.

There is thus a need to provide flexible and more efficient methods for screening suitable multivalent polymers for transfection of cells with active pharmaceutical ingredients. A potential solution has been developed by researchers at the University of Birmingham have developed a novel polymeric scaffold which can be easily functionalised to provide flexible and more efficient methods for transfection of cells with active pharmaceutical ingredients.

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